Multiway sleep-wake cycle regulator
NET 2401
NET 2401 is a patented formulation designed to improve insomnia, featuring Phlomis Umbrosa Turczaninow and HerbEx Polygala Extract as its key active ingredients. Research, including SCIE papers, has demonstrated that NET 2401 increases adenosine receptors and boosts melatonin levels, the sleep hormone. It effectively reduces the time needed to fall asleep, extends overall sleep duration, and shortens recovery time after waking. This leads to improvements not only in the amount of sleep but also in its quality.
Exclusivity
Composition for Prevention or Treatment of Insomnia
| Country | registration number | Country(s) | registration number |
|---|---|---|---|
| South Korea | 10-1106110 | Europe (Germany, France, UK) | 2370072 |
| The United States | 8,372,453 | Japan | 5456152 |
| Canada | 2756742 | China | ZL201080013588.4 |
Mechanism of Action
Regulates sleep pressure by modulating adenosine receptor signaling and increasing melatonin levels, the sleep hormone
Activates adenosine receptors and increases melatonin concentration
Confirmed agonistic activity on adenosine A1 receptorsShows a significant response in human recombinant BA/F3 cells,with activity levels compared to the reference agonist N6-cyclopentyladenosine (CPA)
In a 2-week in vivo test,
Adenosine A1 receptors in brain tissue increased by 280% Caffeine (adenosine A1/A2A receptor antagonist) and DPCPX (adenosine A1 receptor antagonist)
Melatonin levels increased by 43%Improved sleep duration and recovery time
After 2 weeks of administration, in vivo testing with Pentobarbital sleep induction revealed
Sleep latency Reduced by 22%, indicating a shorter time to fall asleep
Sleep durationIncreased sleep duration by 50%
Recovery time reduced by 19%,indicating a quicker start to active movement after wakingFood Science and Biotechnology (2024)
Recommended dosage
960 ~ 1920 mg/day
